	Association of caffeine citrate administration with necrotising enterocolitis in infants < 32 weeks' gestation: a retrospective cohort study. BMJ Open Hu X, Yuan L, Wang Q, Zhu L, Dang D, Fu Y, Gong H, Han S, Yang J, Chinese Neonatal Network. PMID: 42601100 [PubMed - indexed for MEDLINE]
	PROGNOSTIC AND PREDICTIVE VALUE OF TUMOR BUDDING, LYMPHOVASCULAR INVASION, AND PERINEURAL INVASION IN COLORECTAL CARCINOMA ALTIN SALLAHU1, FERAT SALLAHU1. 1DEPARTMENT OF ABDOMINAL SURGERY, UNIVERSITY CLINICAL CENTER OF KOSOVO (UCCK), PRISHTINA, KOSOVO. ABSTRACT. BACKGROUND: COLORECTAL CARCINOMA (CRC) REMAINS ONE OF THE MOST COMMON MALIGNANCIES WORLDWIDE AND A LEADING CAUSE OF CANCER-RELATED MORTALITY. ACCURATE PREDICTION OF RECURRENCE IS ESSENTIAL FOR RISK STRATIFICATION AND INDIVIDUALIZED POSTOPERATIVE MANAGEMENT. THIS STUDY AIMED TO EVALUATE THE PROGNOSTIC AND PREDICTIVE SIGNIFICANCE OF TUMOR BUDDING (TB), LYMPHOVASCULAR INVASION (LVI), AND PERINEURAL INVASION (PNI) IN COLORECTAL CARCINOMA. METHODS: A RETROSPECTIVE COHORT STUDY WAS CONDUCTED INCLUDING PATIENTS TREATED AT THE CLINIC OF ABDOMINAL SURGERY AND THE DEPARTMENT OF PATHOLOGY, UNIVERSITY CLINICAL CENTER OF KOSOVO (UCCK), BETWEEN JANUARY 2020 AND JUNE 2025. FOLLOW-UP DATA COLLECTION CONTINUED UNTIL DECEMBER 2025, AND ONLY PATIENTS WITH A MINIMUM FOLLOW-UP DURATION OF 6 MONTHS WERE INCLUDED IN THE FINAL ANALYSIS. CLINICAL, SURGICAL, AND HISTOPATHOLOGICAL DATA WERE COLLECTED, INCLUDING TB, LVI, AND PNI STATUS. STATISTICAL ANALYSIS INCLUDED DESCRIPTIVE METHODS, CHI-SQUARE TEST, BINARY LOGISTIC REGRESSION, RECEIVER OPERATING CHARACTERISTIC (ROC) CURVE ANALYSIS WITH AREA UNDER THE CURVE (AUC), AND KAPLAN-MEIER DISEASE-FREE SURVIVAL (DFS) ANALYSIS WITH THE LOG-RANK TEST. RESULTS: HIGH TUMOR BUDDING (BD3) WAS IDENTIFIED IN 29.2% OF PATIENTS, LVI IN 34.1%, AND PNI IN 26.7%. AT LEAST ONE INVASIVE HISTOPATHOLOGICAL FACTOR WAS PRESENT IN 48.6% OF THE COHORT. ALL THREE MARKERS WERE SIGNIFICANTLY ASSOCIATED WITH DISEASE RECURRENCE (P < 0.001). MULTIVARIATE LOGISTIC REGRESSION DEMONSTRATED THAT INDEPENDENT PREDICTORS OF RECURRENCE WERE LVI (OR 4.72; 95% CI 2.46-9.03), PNI (OR 3.91; 95% CI 1.98-7.72), AND TB (OR 3.24; 95% CI 1.67-6.29). LVI SHOWED THE HIGHEST PREDICTIVE ACCURACY IN ROC ANALYSIS (AUC = 0.781). KAPLAN-MEIER SURVIVAL ANALYSIS DEMONSTRATED SIGNIFICANTLY SHORTER MEDIAN DISEASE-FREE SURVIVAL (DFS) IN PATIENTS WITH ONE OR MORE POSITIVE INVASIVE HISTOPATHOLOGICAL FACTORS COMPARED WITH PATIENTS WITHOUT SUCH FACTORS. MEDIAN DFS WAS 22.4 MONTHS (95% CI: 18.7-26.1) VERSUS 35.1 MONTHS (95% CI: 31.4-38.8), RESPECTIVELY (LOG-RANK P < 0.001) CONCLUSIONS: TUMOR BUDDING, LYMPHOVASCULAR INVASION, AND PERINEURAL INVASION ARE INDEPENDENT PROGNOSTIC MARKERS IN COLORECTAL CARCINOMA. AMONG THEM, LVI DEMONSTRATED THE STRONGEST PREDICTIVE VALUE FOR RECURRENCE. ROUTINE INCORPORATION OF THESE PARAMETERS INTO PATHOLOGICAL REPORTS MAY IMPROVE PROGNOSTIC ASSESSMENT AND SUPPORT THERAPEUTIC DECISION-MAKING. Georgian Med News Sallahu A, Sallahu F. PMID: 42600587 [PubMed - indexed for MEDLINE]
	Burden of Shigella infection in children under five years living in a peri-urban area of Ouagadougou, Burkina Faso: A community-based cohort study. PLoS Negl Trop Dis Héma A, Sawadogo J, Soulama BI, Hien D, Diarra A, Sermé SS, Ouédraogo AZ, Nébié I, Houard S, Ouédraogo A, Tiono AB, Sanou M, Sirima SB. PMID: 42599952 [PubMed - indexed for MEDLINE]
	Editorial: Toward Prognostic Precision in the Management of Gastroenteropancreatic Neuroendocrine Neoplasms. Cancer Control Ergenç M, Yaz. PMID: 42599881 [PubMed - indexed for MEDLINE]
	Body Mass Index at Diagnosis, Prediagnostic Weight Loss, and Survival in Colorectal Cancer. JAMA Netw Open Mandic M, Wankhede D, Safizadeh F, Hoffmeister M, Brenner H. PMID: 42599706 [PubMed - indexed for MEDLINE]
	Beyond PERISCOPE II: Redesigning Peritoneal-Directed Treatment for Gastric Cancer. J Gastrointest Cancer Burke E. PMID: 42599601 [PubMed - indexed for MEDLINE]
	Radiomics for Prediction of Microsatellite Instability Status in Gastric Cancer: A Systematic Review and Meta-Analysis. J Gastrointest Cancer Gou Q, Wang K, He X, Zhang X. PMID: 42599597 [PubMed - indexed for MEDLINE]
	Relative Dose Intensity and Clinical Outcomes of Using Trifluridine/Tipiracil with or without Bevacizumab in Patients Agedâ€‰â‰¥â€‰75 Years with Advanced or Recurrent Colorectal Cancer: a Single-Center Retrospective Study. J Gastrointest Cancer Tomiuchi A, Kimura M, Ikeda Y, Usami E. PMID: 42599544 [PubMed - indexed for MEDLINE]
	Nationwide Practice Patterns of Early Postoperative Kampo Medicine after Gastrectomy for Gastric Cancer: A Japanese Administrative Database Study. J Gastrointest Cancer Maruyama T, Ikezawa K, Suzuki H, Kurokawa T, Akashi Y, Oda T. PMID: 42599543 [PubMed - indexed for MEDLINE]
	Routine probiotics and outcomes in infantsâ€‰<â€‰29Â weeks: a 13-year single-centre cohort with propensity-weighted sensitivity analyses. Eur J Pediatr Omereji T, Wigston S, Karayaneva Y, Loganathan PK. PMID: 42599538 [PubMed - indexed for MEDLINE]
	Relationship between intussusception and familial Mediterranean fever: a molecular genetic study. Pediatr Surg Int Tartar T, Onalan E, Bakal Ü, Sarac M, Kirik S, Akdeniz , Kazez A. PMID: 42599298 [PubMed - indexed for MEDLINE]
	Ligation-assisted endoscopic mucosal resection versus endoscopic submucosal dissection for small gastrointestinal deep-layer lesions: A retrospective cohort study. J Int Med Res Zhang Q, Zhou Y, Pan P, Hu H, Xiao Z, Liu R, Zhang D, Tang A, Deng M, Wang X, Li J, Wang W. PMID: 42599210 [PubMed - indexed for MEDLINE]
	The Process of Adapting to Altered Bowel Function in Patients With Rectal Cancer: A Grounded Theory Study. Psychooncology Lu LC, Long A, Sun FK. PMID: 42599075 [PubMed - indexed for MEDLINE]
	Prognostic Role of EMR1 in Lymph Nodes and Primary Tumors of Colon Cancer Patients. Adv Biol (Weinh) Roshdy T, Eltorky H, Mohamed A, Zahran F, Guirgis A, Olsson L, Lindmark G, Hammarström ML, Hammarström S, Sitohy B. PMID: 42598774 [PubMed - indexed for MEDLINE]
	Postbleeding antithrombotic management in cardiovascular patients: insights from the Attica Bleeding Snapshot study. Res Pract Thromb Haemost Soulaidopoulos S, Leontsinis I, Chrysochoou C, Dri E, Tatakis F, Kyriazis I, Skopelitis E, Sevastianos V, Korompoki E, Touliatou A, Paraskeva K, Vallianou NG, Tsiodras S, Psyrri A, Manolakopoulos S, Papatheodoridis G, Vassilopoulos D, Tentolouris N, Tsioufis K, Centers and Investigators. PMID: 42598058 [PubMed - indexed for MEDLINE]
	Construction of prognostic models for colorectal cancer based on the perioperative modified Gustave Roussy Immune Score and machine learning. Front Immunol Zhou J, Zhao K, Wei S, Huang S. PMID: 42597619 [PubMed - indexed for MEDLINE]
	An albumin-based immune-nutritional score for predicting complete response, organ preservation, and toxicity after neoadjuvant PD-1-based therapy in low rectal cancer. Front Immunol Fan Y, Zhang M, An K, Wang Z, Meng N, Liu M, Zhang L, Chen Y, Liu F, Dong J, Zhang L, Sun Y, Geng W. PMID: 42597332 [PubMed - indexed for MEDLINE]
	Addressing 'hard-to-fund' research questions in bowel research: Exploring the role of decision architecture randomised trials. Colorectal Dis Chapman SJ, Bisset C, Fowler H, Murray A, Banks J, Kovacs J, Tiernan J, Cornish J, Moug S, Vimalachandran D, Flory JH, Vickers A, Relton C. PMID: 42596504 [PubMed - indexed for MEDLINE]
	Oncological outcomes and treatment characteristics of patients with cT3-4 mesorectal fascia positive rectal cancer operated in 2016: Dutch nationwide cohort with standardized magnetic resonance imaging re-assessment. BJS Open Guicherit JEEA, van Geffen EGM, Sluckin TC, Hazen SJA, Burger JWA, Nederend J, Dekker JWT, de Wilt JHW, Verhoef C, Marinelli AWKS, Melenhorst J, Maas M, Tanis PJ, Dutch Snapshot Research Group, the. PMID: 42594359 [PubMed - indexed for MEDLINE]
	Gastroparesis induced by glucagon-like peptide-1 receptor agonists: A systematic review of clinical features, diagnosis, management, and outcomes. PLoS One Olubodun T, Osundina MA, Soyoye DO, de Oliveira NMB, Olubodun AB, Ogundele OO. PMID: 42594084 [PubMed - indexed for MEDLINE]

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